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Genetic models research has revealed that incorporating specific dietary elements during pregnancy can potentially shield offspring from compromised brain function. Australian scientists from the Monash Institute of Biomedical Discovery have published their conclusions in the esteemed journal Nature Cell Biology.
Research Methodology
Previous studies have highlighted that alterations in the environment and the diet of animals can modify the physiology and development of their offspring. However, the role of maternal nutrition in influencing the heredity of multiple generations has remained insufficiently explored.
To investigate this impact, scientists delved into the study of roundworms (Caenorhabditis elegans) as a genetic model, given that many of their genes are also present in the human body.
Researchers scrutinized brain neurons that connect and communicate with each other through approximately 850,000 kilometers of axons. They uncovered that the fragility of axons, for various reasons, leads to brain dysfunction and neurodegeneration. The team explored whether natural dietary components could stabilize these axons and prevent the causes of fragility.
The study specifically focused on deciphering which particular aspects of a mother’s diet can effectively counteract neurodegeneration.
Maternal Diet Components that Prevent Neurodegeneration
Researchers have pinpointed a crucial compound, ursolic acid, found in apple peels and certain herbs like basil, rosemary, thyme, oregano, and sage. This compound has been demonstrated to play a pivotal role in reducing axonal fragility.
We identified a molecule found in apples and herbs (ursolic acid) that reduces axon fragility. How? We found that ursolic acid causes a gene to turn on that makes a specific type of fat.
Senior author Professor Roger Pocock, Head of the Laboratory of Brain Development, Neuroplasticity and Stem Cells, Monash University, Australia
According to Professor Pokock, a type of fat known as sphingolipid must journey from the mother’s intestines, where food is digested, to the egg cells to safeguard axons in subsequent generations. The outcomes are promising, though they still require validation through human trials.
Professor Pokock further added that this marks the first confirmation of lipid inheritance and, notably, sphingolipid shields in the axons of two succeeding generations. This revelation implies that a mother’s diet can influence not just her children’s brain health but potentially the brain health of subsequent generations as well.
About Ursolic Acid
Before this discovery, ursolic acid was recognized for its role in supporting cardiovascular health. Furthermore, athletes and those aiming to lose weight have utilized it, as it aids in preserving muscle mass.
However, it’s crucial to note that the most effective form of this component is found in its natural state – within apples and leafy greens. Each supplement carries its own set of contraindications. Thus, consuming apples with their skins without hesitation is recommended. But consulting a healthcare professional before considering any supplements is advised.
